In the ending of One Hundred Years of Solitude, I think that Gabriel Garcia Marquez wants one to know that things take time and quite to be done. I also think that he is saying that you may not always be able to teach your findings to anyone that wants to learn it as one may not have another one hundred years to teach his findings and what he has written down on the parchment paper. The characters wanted you to know that these actions are not able to be repeated, as time doesn’t repeat, it will continue and what has happened can’t come back to happen again.
The ending of One Hundred Years of Solitude shows in this one line that you will have to put yourself in a room by yourself and work on something for one hundred years to fully understand why the same person couldn’t recreate and explain their findings.